What is iPS

诱导性多能干细胞（induced pluripotent stem cells，iPS cells）：2006年日本京都大学Shinya Yamanaka在世界著名学术杂志《细胞》上率先报道了诱导多能干细胞的研究。他们把Oct3/4,Sox2、c-Myc和Klf4这四种转录因子基因克隆入病毒载体，然后引入小鼠成纤维细胞，发现可诱导其发生转化，产生的iPS细胞在形态、基因和蛋白表达、表观遗传修饰状态、细胞倍增能力、类胚体和畸形瘤生成能力、分化能力等方面都与胚胎干细胞相似。

23个干细胞研究数据库

• 干细胞百科全书

https://medlineplus.gov/stemcells.html

https://stemcells.nih.gov/

https://www.stembook.org/

http://www.stemcell.net.in/related-links.php

https://stembancc.org/

• 临床试验数据库

https://hsci.harvard.edu/

https://www.eurostemcell.org/

https://www.cirm.ca.gov/

https://hpscreg.eu/

http://stemcellassays.com/

http://www.chictr.org.cn/index.aspx

https://clinicaltrials.gov/

• 组学资源数据库

https://www.cbligand.org/StemCellCKB/login.php

http://servers.binf.ku.dk/bloodspot/

http://stemniche.snv.jussieu.fr/#

https://espresso.teichlab.sanger.ac.uk/index.php

http://stemmapper.sysbiolab.eu/

http://codex.stemcells.cam.ac.uk/

http://www.stemdb.org/

http://www.maayanlab.net/ESCAPE/

• 干细胞细胞系

https://cell.brc.riken.jp/en/

https://www.atcc.org/Products/Cells_and_Microorganisms/Stem_Cells.aspx

https://mrc.ukri.org/

https://www.phe-culturecollections.org.uk/